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Louis San Francisco Auckland Bogota Caracas Lisbon London Madrid Mexico City Milan Montreal New Delhi San Juan Singapore Sydney Tokyo Toronto Mc Graw-Hill l! Except as permitted under the United States Copyright Act of 1976, no part of this publication may be reproduced or distributed in any form or by any means, or stored in a data base or retrieval system, without the prior written permission of the publisher. Library of Congress Cataloging-in-Publication Data Hall, Gary D. Chapter 7 consists of patient profiles, each accompanied by a series of related questions. (E) It directly inhibits the action of mucin in the stomach. Which of the following is true of pilocarpine (Isopto Carpine, Pilostat)? similar pharmacologic action to dorzolamide (Trusopt) II. ingredient in Ocusert ocular therapeutic system (A) I only (B) III only (C) I and II only (D) II and III only (E) I, II, and III (A) gonadotropin-releasing hormone analog (B) estrogen (C) antiestrogen (D) progestin (E) androgen 114. The use of clozapine (Clozaril) has been asso- ciated with the development of (A) thrombocytopenia (B) hypocalcemia (C) meningitis (D) agranulocytosis (E) hematuria 117. tranylcypromine (Parnate) (A) I only (B) III only (C) I and II only (D) II and III only (E) I, II, and III only 130. montelukast sodium (A) I only (B) III only (C) I and II only (D) II and III only (E) I, II, and III only 132. (A) chlorpropamide (Diabinese) (B) lypressin (Diapid) (C) insulin (D) glyburide (Micronase) (E) glucagon 136.

Z A Division of The Mc Graw-Hill Companies Appleton & Lange's Review of Pharmacy, Seventh Edition Copyright © 2001 by The Mc Graw-Hill Companies, Inc. Previous editions copyright © 1997,1993,1990,1985 by Appleton & Lange; © 1980, 1976 by Arco Publishing, Inc. Project management was provided by Rainbow Graphics. Information obtained from the questions and commentaries in Chapters 1 through 6 will probably aid in answering questions in Chapter 7. Which of the following is true of permethrin (Nix, Elimite)? Didanosine (Videx) can best be described as a (an) (A) antiprotozoal (B) reverse transcriptase inhibitor (C) protease inhibitor (D) beta-lactamase inhibitor (E) antifungal 118. A drug indicated for the treatment of both di- arrhea and constipation is Questions: 122-138 (A) bisacodyl (Dulcolax) (C) tramadol (B) lactulose (Cephulac) (D) busulfan (E) milrinone (C) polycarbophil (Mitrolan) (D) senna (Senokot) (E) magnesium sulfate 131. The thiazide derivative diazoxide (Hyper- stat) (A) is a more potent diuretic than hy- (B) (C) (D) (E) drochlorothiazide is not a diuretic produces about the same diuretic response as an equal dose of hydrochlorothiazide is used in the treatment of shock must be used with a potassium supplement 133. In the treatment of cardiac arrhythmias, so- talol (Betapace) is most similar in action to (A) tocainide (B) verapamil (C) amiodarone (D) digoxin (E) flecainide 137. a corticosteroid (C) I and II only (D) II and III only (E) I, II, and III 134.

This recommendation is of particular importance in connection with new or infrequently used drugs. Within each chapter, some questions dealing with related subject matter have been grouped together, whereas others have intentionally not been categorized, necessitating a return to certain areas of study in later questions to reinforce prior learning. describes the mechanism of action of ranitidine (Zantac)?

Seuenth Edition Appleton & Lange's Review of PHA Cy Gary D. In each chapter, questions are followed by an Answers and Explanations section, which we think is the keystone of our book. (A) miotic (B) decreases the production of aqueous humor (C) interferes with the enzyme carbonic anhydrase (D) prostaglandin agonist (E) mydriatic 108. timolol (Timoptic) (A) I only (B) III only (C) I and II only (D) II and III only (E) I, II, and III 112. It is used to enhance permeation of drugs through the skin.

A description of the computer-based examination is provided on page xii. reset the hypothalamic "setpoint" (A) I only (B) III only (C) I and II only (D) II and III only (E) I, II, and III 120. Carbon monoxide exerts its toxic effects pri- marilyby (A) inhibiting the gag reflex (B) decreasing the oxygen-carrying capacity of the blood (C) reacting with amino acids in the body to form ammonia (D) reacting with body enzymes to produce respiratory acidosis (E) paralyzing the muscles of the diaphragm 16 1: Pharmacology 122. Which of the following drugs may interfere with ethanol metabolism? Which of the following agents is (are) classi- fied pharmacologically as carbonic anhydrase inhibitors? The renal excretion of amphetamines can be diminished by alkalinization of the urine. Vidarabine (Vira-A) is an antiviral agent indicated for the treatment of (A) rubella (B) AIDS (C) influenza (D) herpes simplex encephalitis (E) pneumocystis carinii pneumonia (PCP) 140.

There are also two appendices: the first lists more than 200 drugs by generic names that the authors consider most likely to be dispensed by pharmacists. The "first-dose" effect is characterized by marked hypotension and syncope on taking the first few doses of medication. The most serious potential consequence of ingestion of a liquid hydrocarbon such as kerosene or gasoline is (A) inactivation of hepatic enzymes (B) the corrosive action of the poison on the stomach lining (C) the paralysis of peristaltic motion of the GI tract (D) dissolution of the mucus coat of the esophagus (E) the aspiration of the poison into the respiratory tract ish the excretion rate of amphetamine sulfate? Dalteparin sodium (Fragmin) acts in the body to (A) regulate menstrual activity (B) prevent blood dot formation (C) inhibit thyroid function (D) inhibit viral replication (E) reduce the secretion of acid in the stomach 141. human immunodeficiency virus (HIV) infection (A) I only (B) III only (C) I and II only (D) II and III only (E) I, II, and III 142.

Practicing pharmacists must not only retain their previously acquired knowledge and skill, but must remain up to date on contemporary modes of practice. Which of the following statements is (are) TRUE of buprenorphine (Buprenex)? Potassium depletion is LEAST likely to occur in a patient using (A) ethacrynic acid (Edecrin) (B) triamterene (Dyrenium) (C) torsemide (Demadex) (D) acetazolamide (Diamox) (E) chlorthalidone (Hygroton) 155.

We hope that this book will serve both as a means for selfassessment of competence to practice as well as a valuable guided review. Acyclovir (Zovirax) is indicated for the treat- ment of (A) multiple sclerosis (B) psoriasis (C) HIV infection (D) shingles (E) mononucleosis 156.

However, in view of the possibility of human error or changes in medical sciences, neither the authors nor the publisher nor any other party who has been involved in the preparation or publication of this work warrants that the information contained herein is in every respect accurate or complete, and they disclaim all responsibility for any errors or omissions or for the results obtained from use of the information contained in this work. A candidate preparing for the licensing examination must be prepared to demonstrate competence in many areas, anyone of which may be the subject for in-depth questioning. Prolonged activity (8 to 10 hours) is an advantage in the use of which of the following topical decongestants? Which of the following agents is NOT likely to reduce blood sugar in a patient with type II diabetes mellitus? Which of the following statements is (are) true of regular insulin? Gastric intrinsic factor is a glycoprotein that is required for the gastrointestinal absorption of (A) medium chain triglycerides (B) folic acid (C) iron (D) cyanocobalamin (E) tocopherols 14 1: Pharmacology 106. Which one of the following is an effect of at- are adverse effects associated with the use of ropine on the human body?

Included in the table are trade or brand names, manufacturing companies, a brief description of therapeutic uses, and common dosage forms and strengths. Washington, DC: American Pharmaceutical Association, 1996. Zidovudine (Retrovir) is indicated for the treatment of patients with I. Which of the following is (are) true of alteplase (Activase)? nedocromil sodium (Tilade) (A) I only (B) III only (C) I and II only (D) II and III only (E) I, II, and III 144.

It is NOT necessary to memorize the name of the company manufacturing a certain product, especially with the numerous company name changes. (A) derived from bovine tissue (B) administered intramuscularly (C) derived from porcine tissue (D) an anticoagulant (E) a thrombolytic agent 143. Didofenac sodium (Voltaren) is most similar in action to (A) buspirone (Bu Spar) (B) oxaprozin (Daypro) (C) chlorzoxazone (Paraflex) (D) dicydomine (Bentyl) (E) mecamylamine (Inversine) 145. amlodipine (Norvasc) (A) I only (B) III only (C) I and II only (D) II and III only (E) I, II, and III 147. (A) I only (B) III only (C) I and II only (D) II and III only (E) I, II, and III 150. (A) norethynodrel (B) norethindrone (C) mestranol (D) levonorgestrel (E) ethynodiol diacetate 151.

We trust that this book will not be viewed as simply a means to review material for the licensing examination. Reflex tachycardia is an adverse effect most likely to be associated with the use of which of the following drugs? Danazol (Danocrine) can best be classified as a (an) (A) anti-inflammatory corticosteroid (B) estrogen (C) progestin (D) neuromuscular blocking agent (E) androgen 19 153.

Passing this examination does not guarantee continued competence throughout a long professional career. USP DI Volume III-Approved Drug Products and Legal Requirements. Questions: 139-157 (A) minoxidil (Loniten) (B) losartan (Cozaar) (C) moexipril (Univasc) (D) nadolol (Corgard) (E) clonidine (Catapres) 149. Torsemide (Demadex) is most similar in ac- tion to (A) bumetanide (Bumex) (B) risperidone (Risperdal) (C) spironolactone (Aldactone) (D) chlorthalidone (Hygroton) (E) acetazolamide (Diamox) 154.

worried about the camels", the winner was, in fact, one of the horses ... Pharmaceutical Compounding Questions Answers and Explanations 117 118 133 5. Nerves in the human body that transmit their impulses by releasing acetylcholine are known as nerves. narcotic antagonist (A) I only (B) III only (C) I and II only (D) II and III only (E) I, II, and III (D) II and III only (E) I, II, and III 75. Which of the following is an active metabo- lite of primidone (Mysoline)? Which one of the following is an example of a pure narcotic antagonist? succinylcholine chloride (A) I only (B) III only (C) I and II only (A) Crohn's disease (B) Meniere's syndrome (C) Paget's disease (D) Hansen's disease (E) Parkinson's disease 78. nalbumetone (Relafen) (A) I only (B) III only (C) I and II only (D) II and III only (E) I, II, and III 81. is an artificial sweetener 11 (A) I only (B) III only (C) I and II only (D) II and III only (E) I, II, and III 84. Phosphate binding is likely to occur when which of the following antacids are administered? (A) misoprostol (Cytotec) (B) ritodrine (Yutopar) (C) mesalamine (Asacol) (D) metoclopramide (Reglan) (E) omeprazole (Prilosec) 12 1: Pharmacology 88. ibuprofen (A) I only (B) III only (C) I and II only (D) II and III only (E) I, II, and III 89. (A) I only (B) III only (C) I and II only (D) II and III only (E) I, II, and III 100.

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